The Complement System A group of 30 plasma proteins which comprise the primary soluble component of innate immunity. Rapidly activated in response to infection, without induction or recall of adaptive immunity
The Complement System A group of > 30 plasma proteins which comprise the primary soluble component of innate immunity. Rapidly activated in response to infection, without induction or recall of adaptive immunity
The Complement System However,in the presence of an adaptive immune response,complement proteins interact with both its soluble and cellular components (antibodies,lymphocytes, activated macrophages,dendritic cells). Complement proteins circulate in plasma as inactive precursors
The Complement System However, in the presence of an adaptive immune response, complement proteins interact with both its soluble and cellular components (antibodies, lymphocytes, activated macrophages, dendritic cells). Complement proteins circulate in plasma as inactive precursors
The Complement System Infection results in activation of complement proteins via a series of proteolytic reactions that yield biologically active fragments. These coupled proteolytic reactions result in an amplification cascade,in which limited stimulation of proximal complement components results in massive activation of distal complement proteins
The Complement System Infection results in activation of complement proteins via a series of proteolytic reactions that yield biologically active fragments. These coupled proteolytic reactions result in an amplification cascade, in which limited stimulation of proximal complement components results in massive activation of distal complement proteins
Complement System:Overview CLASSICAL PATHWAY LECTIN PATHWAY ALTERNATIVE PATHWAY Antigen:antibody complex Lectin binding to pathogen Pathogen surfaces surfaces Complement activation Recruitment of Opsonization Kiling inflammatory cells of pathogens of pathogens Rin
Complement System: Overview
Small complement-cleavage products act on blood vessels to increase vascular permeability 3a Increased permeability allows increased Migration of macrophages,polymorphonuclear fluid leakage from blood vessels leukocytes(PMNs),and lymphocytes is and extravasation of immunoglobulin increased.Microbicidal activity of and complement molecules macrophages and PMNs is also increased gG complement components