Hepatic insufficiency Wang Jing-jing Esophagus Pancreas stomach Transvers Department of Descending colon Duodenum Pathophysiology Ascending Colon sigmoid colon Shandong University
Hepatic insufficiency Wang Jing-jing Department of Pathophysiology Shandong University
■ ntroduction ■ Concept a etiology and classification a The functional and metabolic changes a Hepatic encephalopathy
◼ Introduction ◼ Concept ◼ Etiology and classification ◼ The functional and metabolic changes ◼ Hepatic encephalopathy 2
☆ Introduction Blood Supply antenor vona cava Portal vein 3/4 of the hepatic voin blood flow(which drains the stomach, intestine nes to stvo tract spleen, and pancreas Hepatic artery: 1/4 of pota vein the blood flow
3 ❖ Introduction 1. Blood Supply: Portal vein: 3/4 of the blood flow (which drains the stomach, intestine, spleen, and pancreas) Hepatic artery: 1/4 of the blood flow
2. Internal Structure: Liver lobule Liver Lobule a Acentral vein(coalesce into hepatic veins, which empty Detail of Lobule into the vena cava) Branch of 04-6 portal triad(branches of hepatic artery, hepatic portal Bile duct vein and bile duct) Branch of hepatic portal vein
2. Internal Structure: Liver lobule ❑ A central vein (coalesce into hepatic veins, which empty into the vena cava) ❑ 4-6 portal triad (branches of hepatic artery, hepatic portal vein and bile duct)
Rows of liver cells(Hepatocytes, hepatic stellate cells, sinusoidal endothelial cells Kupffer cells and liver- associated lymphocytes which are in close contact with blood-filled sinusoids Sinusoidal Endothelial Cell Kuppfer Cell Sinusoid - Stellate Cell Central vein P°° hepatocyte Liver hepatic lobule
Rows of liver cells (Hepatocytes, hepatic stellate cells, sinusoidal endothelial cells, Kupffer cells and liverassociated lymphocytes which are in close contact with blood-filled sinusoids