opIcs Introduction Neuroendocrinology Functions of other endocrine glands Thyroid hormone Regulation of calcium and phosphorus metabolism Insulin Glucocorticoid Catecholamine
Topics ◼ Introduction ◼ Neuroendocrinology ◼ Functions of other endocrine glands • Thyroid hormone • Regulation of calcium and phosphorus metabolism • Insulin • Glucocorticoid • Catecholamine
Part 1 Introduction 1. Empirical endocrinology ·BC2000 Castration 1543 Vesalius.,“ pituata”→“ pituitary” 1835 Graves disease ·1855 Claud bernard,“ endocrine” Addison's disease 1889 Brown- Squard,“ Brown- Sequard elixir
• BC2000 Castration • 1543 Vesalius, “pituata” → “pituitary” • 1835 Graves disease • 1855 Claud Bernard, “endocrine” Addison's disease • 1889 Brown-Squard, “ Brown-Séquard Elixir” Part 1 Introduction 1. Empirical endocrinology
2. experimental endocrinology 1902 Bayliss Starling and bayliss Starling, secretin 1905 Hard. hormone° Earnest Henry Starling Sir William Mad dock Bayliss Died 2nd May Born 2nd May
• 1905 Hardy, “hormone” • 1902 Bayliss & Starling, “secretin” 2. experimental endocrinology
3. neuroendocrinology Neurons synthesizing HYPOTHALAMUS posterior pituitary horn ·1928 Ernest Sharrer Neurons synthesizing rophic hormones neurosecretion, neuroendocrine 1949 Bargmann 1955 Harris 1960 Yalow. Berson Portal vessels cells radio-immunoassay, RIA + Artery Axon terminals 1977 Guillemin、 Schally of hypothalamic neurons POSTERIOR Nobel prize PITUITARY ANTERIOR Vein PITUITARY
• 1928 Ernest Sharrer neurosecretion， neuroendocrine • 1949 Bargmann • 1955 Harris • 1960 Yalow, Berson radio-immunoassay, RIA •1977 Guillemin、Schally Nobel Prize 3. neuroendocrinology
4 neuroendocrine-immune network 应激刺激等 ·1977 Besedovskyn 可感知刺激 枢神经系统 神经内分泌途径 肾上腺、性腺 和甲状腺激素 促营养激素 B细胞 病 内分泌系统 激素 免疫因乙免疫系统」刺 T细胞 ⊙ 激 细胞因子 胸腺激素 Did you find common features呀子 噬细胞 免疫细胞分泌的 蛋白质和肽类激素 of these three systems? 抗原等制敌
4. neuroendocrine-immune network • 1977’ Besedovskyn Did you find common features of these three systems?