Lecture 16 Cellular Cooperation and Antigen Recognition
Lecture 16 Cellular Cooperation and Antigen Recognition
Cellular Cooperation antigen Plasma Cells Antigen presentation to T and B cells by APC T cells elaborate cytokines to Antibody secretion by Antigen presenting cell facilitate B cell proliferation plasma cells and maturation
Cellular Cooperation TH B antigen Antibody secretion by plasma cells Plasma Cells Antigen presenting cell Antigen presentation to T and B cells by APC T cells elaborate cytokines to facilitate B cell proliferation and maturation
Antigen Presenting Cells Must be capable of processing antigen from extracellular and intracellular pathogens Must present processed antigen on MHC class I&II molecules Must express co-stimulatory molecules (cytokines)
Antigen Presenting Cells ◼ Must be capable of processing antigen from extracellular and intracellular pathogens ◼ Must present processed antigen on MHC class I & II molecules ◼ Must express co-stimulatory molecules (cytokines)
Types of Professional Antigen Presenting Cells Macrophages/monocytes Dendritic cells (e.g..,Langerhan's cells) B cells
Types of Professional Antigen Presenting Cells ◼ Macrophages/monocytes ◼ Dendritic cells (e.g.., Langerhan’s cells) ◼ B cells
Macrophages Dendritic cells B cells Properties of Professional Antigen- Presenting +++Phagocylosis by Antigen-specific Cells Antigen Phagocytosis uptake tissue dendritic cels. reoeptor (lg) +++ ++Viral infection ++++ MHC Inducble by bacteria and cytokines Constitutive Constitutive. expression Increases on activation -b+++ +++ +++0++++ Co-stimulator Constitutive;by mature Inducble Inducble delivery 一o+++ np089828oo -0++ ++十+ Antigen Particulate antigens. Peptides Soluble antigens. presented Intracellular and Viral antigens Toxins. extraoellular pathogens (allergens?) Viruses Lymphold tissue Lymphoid tissue. Location Connective tissue Connedtive tissue Lymphoid tissue. Body cavities Epithelia Peripheral blood @1997 Current Biology Ltd./Garland Publishing,Inc
Properties of Professional AntigenPresenting Cells