Lecture 13 Antigens,Receptors and Immunoglobulins
Lecture 13 Antigens, Receptors and Immunoglobulins
Antigenic Determinants(Epitopes) Haptenic determinant Conformational Antigenic Determinant ●舍 Sequential antigenic deferminant
Antigenic Determinants (Epitopes)
Receptor-Epitope Concepts Most biological systems can be viewed in terms of interactions between receptors and epitopes (hand and glove"). Specificity of the interaction between the receptor and epitope is determined by the amino acid sequence of the receptor ("tailoring the glove"). If the glove is too big,the glove falls off. If the glove is too small,you can't get your hand into it. If the glove is missing fingers
Receptor-Epitope Concepts ◼ Most biological systems can be viewed in terms of interactions between receptors and epitopes (“hand and glove”). ◼ Specificity of the interaction between the receptor and epitope is determined by the amino acid sequence of the receptor (“tailoring the glove”). ◼ If the glove is too big, the glove falls off. ◼ If the glove is too small, you can’t get your hand into it. ◼ If the glove is missing fingers…
Examples of Receptor-Epitope Interactions Enzymatic reactions Antigen recognition Antigen-Antibody reactions Biological chaperones(stress proteins) Cellular communications Cell-mediated cytotoxicity Cellular homing (MALT,chemotaxis,etc.)
Examples of Receptor-Epitope Interactions ◼ Enzymatic reactions ◼ Antigen recognition ◼ Antigen-Antibody reactions ◼ Biological chaperones (stress proteins) ◼ Cellular communications ◼ Cell-mediated cytotoxicity ◼ Cellular homing (MALT, chemotaxis, etc.)
Basic Immunoglobulin Structure light chain disufide bridges heavy chain @1997 Current Biology Ltd./Garland Publishing,Inc
Basic Immunoglobulin Structure