The Immune System Innate ·Acquired(Adaptive) ·Antimicrobial -B Lymphocytes Peptides Antibody ·Phagocytes (Macrophages,PMNs, -T Lymphocytes Monocytes,DCs) Cytotoxicity Help”Antibody 。Alternative Cytokine Secretion Complement System BDC
The Immune System • Innate • Antimicrobial Peptides • Phagocytes (Macrophages, PMNs, Monocytes, DCs) • Alternative Complement System • Acquired (Adaptive) -B Lymphocytes Antibody -T Lymphocytes Cytotoxicity “Help” Antibody Cytokine Secretion BDC
B and T Lymphocyte Antigen Receptors VB Va y E CB Co CH2 CH2 Iga/IgB CH3 CH3 Iga/IgB fyn Blk,Fyn or Lyn φ派 2 light chains(orK) 2 Chains a/B(95%)ory/(5%) 2 heavy chains(5 isotypes:IgG,M,A,D,E) 2 Binding sites(Divalent) 1 Binding site(Monovalent) Secreted into circulation Membrane Bound,Not Secreted Binds Soluble Antigen Binds Antigen Complexed with MHC BDC
2 light chains ( or ) 2 heavy chains (5 isotypes: IgG, M, A, D, E) 2 Binding sites (Divalent) Secreted into circulation Binds Soluble Antigen 2 Chains / (95%) or / (5%) 1 Binding site (Monovalent) Membrane Bound, Not Secreted Binds Antigen Complexed with MHC Zap 70 fyn lck e z V V C C CH1 CH2 CH3 CH2 CH3 CH1 CL CL VL VL VH VH e z Ig/Ig Ig/Ig Blk, Fyn or Lyn B and T Lymphocyte Antigen Receptors BDC
XPID:X-linked polyendocrinopathy, immune dysfunction and diarrhea ·XLAAD:“Autoimmunity Allergic Dysreg Scurfin gene (Foxp3/JM2) Immunopathogenesis:Th2 Cytokines, abnormal activation (I1-4,5,13) -Scurfy+Nude:No Autoimmunity -CD4+into Nude:Disease -Bone Marrow into irradiated:No Disease -Require Antigen Stimulation for Disease -Mixed Chimera:No Disease BDC
XPID: X-linked polyendocrinopathy, immune dysfunction and diarrhea • XLAAD: “Autoimmunity Allergic Dysreg” • Scurfin gene (Foxp3/JM2) • Immunopathogenesis: Th2 Cytokines, abnormal activation (Il-4,5,13) -Scurfy+Nude: No Autoimmunity -CD4+ into Nude: Disease -Bone Marrow into irradiated: No Disease -Require Antigen Stimulation for Disease -Mixed Chimera: No Disease BDC
J.Noble HLA Human Leukocyte Antigen human MHC cell-surface proteins important in self vs.nonself distinction present peptide antigens to T cells CLASS I:A.B.C CLASS II:DR,DQ,DP
Human Leukocyte Antigen human MHC cell-surface proteins important in self vs. nonself distinction present peptide antigens to T cells CLASS I: A,B,C CLASS II: DR,DQ,DP HLA J. Noble
The Human Leukocyte Antigen Complex (6p21.31) Class Ill Class ll (1.1 Mb) (0.7Mb) Class I (2.2Mb) DP DO DR B C elomere Frequent Class I-like genes Recombination Complement and pseudogenes and Cytokines Recombination Recombination is Rare is Rare BDC
The Human Leukocyte Antigen Complex (6p21.31) DP DQ DR B C A Class II (1.1 Mb) Class III Class I (2.2Mb) Complement and Cytokines Class I-like genes and pseudogenes Frequent Recombination Recombination is Rare Telomere Centromere Recombination is Rare (0.7Mb) BDC